NCIt synonyms : (79-L-aspartic Acid(L D))Human Activin Receptor Type-2B (ACTR-IIB, EC 2.7.11.30) Precursor-(25-131)-peptide
(Extracellular Domain Fragment) Fusion Protein with Triglycyl-human Immunoglobulin
Heavy Constant Gamma 1 Fc Fragment-(8-232)-peptide Dimer (114-114':117-117')-bisdisulfide; Luspatercept-aamt;
NCIt definition : A soluble, recombinant fusion protein composed of a modified form of the extracellular
domain of human activin receptor type IIb (ActRIIb) and linked to the human IgG1 Fc
domain, with red blood cell stimulating activity. Upon subcutaneous administration,
luspatercept inhibits several ligands in the transforming growth factor (TGF)-beta
superfamily. This prevents activation of a variety of TGF-beta superfamily members
involved in late stage erythropoiesis and results in an increased differentiation
and proliferation of erythroid progenitors. luspatercept acts at a different, later
stage than erythropoietin. This agent ultimately enhances red blood cell production
and prevents anemia.;