Preferred Label : Technetium Tc 99m-3PRGD2;
NCIt synonyms : (99m)Tc-PEG(4)-E[PEG(4)-c(RGDfK)](2) ((99m)Tc-3PRGD2); 99mTc-3PRGD2;
NCIt definition : A radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid
(RGD) dimer (PRGD2) labeled with technetium Tc 99m, with potential alphaVbeta3 integrin
imaging activity when used with single photon emission computed tomography (SPECT).
After intravenous administration of technetium Tc 99m-3PRGD2, the RGD moiety binds
to alphaVbeta3 integrin on the cell membrane via the cyclic RGD motif. Upon PET imaging,
alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels
can be quantified. Compared to other radiolabeled RGD-containing peptides, this agent
shows an increased affinity for alphaVbeta3 integrin, enhanced tumor uptake as well
as improved pharmacokinetics. AlphaVbeta3 integrin, a member of the integrin receptor
family, is overexpressed on certain tumor cells and tumor endothelial cells while
minimally or not expressed on healthy, normal cells; this receptor plays a key role
in angiogenesis, tumor proliferation and survival.;
NCI Metathesaurus CUI : CL438389;
Origin ID : C104007;
UMLS CUI : C3641686;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
