Preferred Label : Topical Cocaine Hydrochloride;
NCIt definition : A topical formulation of the hydrochloride salt of the tropane alkaloid cocaine, with
local anesthetic activity. Upon topical application of the cocaine hydrochloride solution
to nasal mucous membranes, cocaine reversibly binds to and blocks the voltage-gated
sodium channels in the neuronal cell membranes. By stabilizing neuronal membranes,
cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible
loss of sensation.;
NCI Metathesaurus CUI : CL438387;
Origin ID : C104004;
UMLS CUI : C3641683;
Semantic type(s)
- concept_is_in_subset
