Preferred Label : Gallium Ga 68-labeled DOTA Di-HSG Peptide IMP-288;
NCIt synonyms : Ga-68-IMP-288;
NCIt definition : A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with
the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
(DOTA) to the radionuclide gallium (Ga) 68 with potential use in diagnostic imaging.
After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against
both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion
of administered gallium Ga 68-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG
portion of the BiMoAB; Ga-68 radioisotopic activity localized to tumor cells bearing
the TAA can then be visualized upon positron emission tomography (PET).;
NCI Metathesaurus CUI : CL438342;
Origin ID : C103864;
UMLS CUI : C3641663;
Semantic type(s)
- concept_is_in_subset
