Preferred Label : Anti-ErbB3 Monoclonal Antibody REGN1400;
NCIt related terms : REGN-1400;
NCIt definition : A human monoclonal antibody directed against the human epidermal growth factor receptor
ErbB3 (Her3) with potential antineoplastic activity. Upon administration, anti-ErbB3
monoclonal antibody REGN1400 binds to ErbB3 and prevents neuregulin 1 ligand binding
to ErbB3, which may result in an inhibition of ErbB3-dependent phosphatidylinositol-3
kinase (PI3K)/Akt signaling. This eventually leads to the inhibition of cellular proliferation
and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR)
family of receptor tyrosine kinases, is frequently overexpressed in a variety of solid
tumors and its overexpression generally correlates with poor prognosis and tumor resistance.;
UNII : 93F274N35Z;
CAS number : 1443016-81-6;
Molecule name : REGN-1400; REGN 1400;
NCI Metathesaurus CUI : CL438337;
Origin ID : C103859;
UMLS CUI : C3641658;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
