Preferred Label : FAP-specific CD8-positive T Cells;
NCIt definition : A preparation of CD8-positive T cells specific for human fibroblast activating protein
(FAP) with potential immunopotentiating activity. T cells have been genetically modified
to express a chimeric antigen receptor specific for FAP. Upon infusion, the FAP-specific
CD8-positive T cells bind to FAP-expressing tumor cells and exhibit a selective toxicity
to tumor cells. This may result in both tumor cell lysis and inhibition of tumor cell
growth. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated fibroblasts
but minimally expressed on normal, healthy cells.;
NCI Metathesaurus CUI : CL438309;
Origin ID : C103829;
UMLS CUI : C3641631;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
