Preferred Label : Galectin-1 Inhibitor OTX008;
NCIt synonyms : Gal-1 Inhibitor OTX008;
NCIt related terms : OTX-008;
NCIt definition : A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic
and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor
OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteasomal degradation, through
an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1.
This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional
carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key
role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune
responses.;
UNII : 8JI63CFH5V;
CAS number : 286936-40-1;
Molecule name : OTX008; KM-0118;
Origin ID : C103828;
UMLS CUI : C3641630;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
