" /> Galectin-1 Inhibitor OTX008 - CISMeF





Preferred Label : Galectin-1 Inhibitor OTX008;

NCIt synonyms : Gal-1 Inhibitor OTX008;

NCIt related terms : OTX-008;

NCIt definition : A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteasomal degradation, through an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.;

UNII : 8JI63CFH5V;

CAS number : 286936-40-1;

Molecule name : OTX008; KM-0118;

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29/07/2025


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