" /> Pasotuxizumab - CISMeF





Preferred Label : Pasotuxizumab;

NCIt definition : A recombinant T-cell engaging bispecific monoclonal antibody (BiTE) directed against human prostate specific membrane antigen (PSMA) and the CD3 epsilon subunit of the T cell receptor complex, with potential immunostimulating and antineoplastic activities. Pasotuxizumab possesses two antigen-recognition sites, one for PSMA, and one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR). This bispecific monoclonal antibody brings PSMA-expressing tumor cells and cytotoxic T lymphocytes (CTLs) together, which may result in the CTL-mediated cell death of PSMA-expressing cells. PSMA, a tumor associated antigen, is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.;

UNII : 9J6SW7G28J;

CAS number : 1442657-12-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1442657-12-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BAY2010112; MT112; AMG-212;

NCI Metathesaurus CUI : CL438307;

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15/05/2024


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