NCIt definition : A recombinant T-cell engaging bispecific monoclonal antibody (BiTE) directed against
human prostate specific membrane antigen (PSMA) and the CD3 epsilon subunit of the
T cell receptor complex, with potential immunostimulating and antineoplastic activities.
Pasotuxizumab possesses two antigen-recognition sites, one for PSMA, and one for the
CD3 complex, a group of T cell surface glycoproteins that complex with the T cell
receptor (TCR). This bispecific monoclonal antibody brings PSMA-expressing tumor cells
and cytotoxic T lymphocytes (CTLs) together, which may result in the CTL-mediated
cell death of PSMA-expressing cells. PSMA, a tumor associated antigen, is overexpressed
on the surface of metastatic and hormone-refractory prostate cancer cells.;