Preferred Label : Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet;
NCIt definition : A prolonged-release tablet formulation composed of the hydrochloride salt form of
the opioid receptor agonist oxycodone and the hydrochloride salt form of the opioid
receptor antagonist naloxone which may produce analgesia while relieving opioid-mediated
gastrointestinal (GI) side effects. Upon oral administration, oxycodone binds to opioid
receptors, thereby mimicking the effects of endogenous opiates to provide analgesia.
As naloxone is very poorly absorbed, this agent binds locally to opiate receptors
in the GI tract, thereby preventing oxycodone from binding to these receptors. This
relieves the opioid-related side effects on the GI tract, including opioid-induced
constipation.;
Drug name : Targinact; Targin;
Origin ID : C103824;
UMLS CUI : C3641625;
Semantic type(s)
- concept_is_in_subset
