Preferred Label : Amnion-derived Cellular Cytokine Solution;
NCIt synonyms : ACSS;
NCIt definition : A topical cellular cytokine solution containing a distinct combination of growth factors
and cytokines secreted by and released from amnion-derived multipotent progenitor
(AMP) cells, with potential immunomodulating and skin healing activities. The amnion-derived
cellular cytokine solution (ACCS) contains near physiological levels of transforming
growth factor beta, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2, as
well as the angiogenesis factors platelet-derived growth factor (PDGF), vascular endothelial
growth factor (VEGF) and angiogenin that are normally found in healing wounds. Upon
spraying the solution onto affected areas, the cytokines and growth factors in ACCS
appear to increase the migration, proliferation and differentiation of both keratinocytes
and fibroblasts; enhance the migration and phagocytosis of macrophages in wounds;
and increase epithelialization. Together these processes may accelerate skin healing
and tissue repair. Also, ACCS may be beneficial in the treatment of radiation burns
of the skin.;
NCI Metathesaurus CUI : CL438304;
Origin ID : C103821;
UMLS CUI : C3641622;
Semantic type(s)
- concept_is_in_subset
