Preferred Label : Nucleolin Antagonist IPP-204106N;
NCIt definition : A synthetic, multivalent, lysine-rich, pseudopeptide and nucleolin antagonist with
potential anti-angiogenic, antineoplastic and pro-apoptotic activities. Upon administration,
IPP-204106N antagonizes nucleolin leading to a downregulation of cell-surface nucleolin;
preventing the binding of certain growth promoting ligands to nucleolin may suppress
tumor cell proliferation and angiogenesis. In addition, IPP-204106N is able to translocate
to the nucleolus and bind to nucleolar nucleolin. This prevents nucleolin from binding
to and stabilizing mRNA of the anti-apoptotic Bcl2; destabilizing Bcl2 mRNA leads
to a reduction in Bcl2 protein synthesis and induces apoptosis. Further, this agent
can antagonize nucleophosmin. Nucleolin, a nucleolar phosphoprotein, is overexpressed
on the cell surface of certain cancer cells and binds ligands involved in cell proliferation,
adhesion and angiogenesis.;
Molecule name : IPP-204106; N6L;
Origin ID : C103297;
UMLS CUI : C3641183;
Semantic type(s)
- concept_is_in_subset
