Preferred Label : Fluorine F 18 d-FMAU;
NCIt synonyms : 2'-Deoxy-2'-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil; 1-(2'-Deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl)thymine; 18F-FMAU;
NCIt related terms : 5-METHYL-2'-FLUOROARAURACIL F-18;
NCIt definition : A radioconjugate comprised of the synthetic pyrimidine analogue 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine
(d-FMAU) labeled with the radioisotope fluorine F 18 (18F-d-FMAU), that can potentially
be used as an imaging agent upon positron emission tomography (PET). Upon administration,
fluorine F 18 FMAU is distributed and taken up by cells based on the rate of the cell's
DNA synthesis. Upon PET imaging, cell proliferation in tumors can be assessed as tumor
cells have a higher rate of DNA synthesis than normal, healthy cells. This agent is
not catabolized and has a long half-life compared to the radioconjugate carbon C 11
thymidine.;
UNII : J932A2CDQO;
CAS number : 241144-93-4;
NCI Metathesaurus CUI : CL438129;
Origin ID : C103278;
UMLS CUI : C5139770;
Semantic type(s)
concept_is_in_subset