Preferred Label : Pegylated Liposomal Mitomycin C Lipid-based Prodrug;
NCIt synonyms : PL-MLP;
NCIt related terms : JNJ-27548547;
NCIt definition : A pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic
antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential
antineoplastic activity. Upon administration of the pegylated liposomal mitomycin
C lipid-based prodrug, the MLP moiety becomes activated upon thiolysis at the tumor
site, thereby releasing mitomycin C. Bioreduced mitomycin C generates oxygen radicals,
alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.
The thiolytic environment and upregulated expression of thioredoxins at the tumor
site allow for the activation and release of mitomycin C. This prodrug formulation
allows for greater circulation time, less systemic toxicity and increased accumulation
of mitomycin C at the tumor site.;
UNII : 3I8JKL1CHB;
CAS number : 303983-00-8;
Drug name : Promitil;
Molecule name : JNJ-27548547;
NCI Metathesaurus CUI : CL438127;
Origin ID : C103276;
UMLS CUI : C3641172;
Semantic type(s)
- concept_is_in_subset
