NCIt definition : A humanized monoclonal antibody directed against the Notch-1 receptor with potential
antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the
cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation.
Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as
a receptor for membrane bound ligands and has various roles during development; dysregulated
Notch signaling is associated with increased cell growth and chemoresistance in cancers.;
Semantic type(s)