Preferred Label : Nitroglycerin Transdermal Patch;
NCIt synonyms : Glyceryl Trinitrate Transdermal Patch; GTN Transdermal Patch;
NCIt definition : A sustained release transdermal patch containing the organic nitrate nitroglycerin,
with vasodilator and potential immunomodulating activities. Upon application to the
skin, nitroglycerin is continuously released from the patch and absorbed. In turn,
nitroglycerin is converted into nitric oxide (NO), which activates guanylyl cyclase,
increasing cyclic guanosine monophosphate concentration thus resulting in smooth muscle
relaxation. In addition, activation of NO-mediated signaling pathways may inhibit
hypoxia-induced tumor cell invasiveness, chemoresistance, evasion of immune cell recognition
and cancer cell progression. Particularly, reactivation of NO-mediated signaling appears
to inhibit the increased tumor cell shedding of the major histocompatibility complex
class I chain-related (MIC) molecules MICA and MICB as is seen in hypoxic tumor environments;
MIC molecules play key roles in tumor cell immune surveillance through their interaction
with the C-type lectin-like NKG2D receptor on natural killer, lymphokine-activated
killer and effector T cells.;
Drug name : Minitran;
Origin ID : C103272;
UMLS CUI : C0699222;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
