Preferred Label : Tumor-Cells Apoptosis Factor Hormone-Peptide;
NCIt related terms : NEROFE;
NCIt definition : A synthetic 14-amino acid peptide derived from a novel human peptide hormone, Tumor-Cells
Apoptosis Factor (TCApF), with potential antineoplastic activity. Upon intravenous
administration, tumor-cells apoptosis factor hormone-peptide binds to the T1/ST2 receptor
(IL1RL1) and activates both caspase 8 and Bcl-2 mediated apoptosis, in addition to
the activation of p38 MAPK and JNK signaling cascades in tumor cells. Furthermore,
this agent inhibits angiogenesis by suppressing the expressions of vascular endothelial
growth factor A (VEGFA) and fms-related tyrosine kinase 1 (VEGFR1). Tumor-cells apoptosis
factor hormone-peptide also modulates immune system responses via increasing the expressions
of interleukin-10 and anti-angiogenic interleukin. T1/ST2 receptor, a member of the
toll/interleukin-1 receptor superfamily, is overexpressed in certain cancer cells.;
UNII : SR717JCM7M;
CAS number : 2120397-85-3;
Drug name : Nerofe;
Origin ID : C103193;
UMLS CUI : C3641121;
Semantic type(s)
- concept_is_in_subset
- has_target
