Preferred Label : Plasmacytoid Dendritic Cell Vaccine;
NCIt synonyms : pDC Vaccine;
NCIt definition : A whole cell vaccine derived from a distinct subset of dendritic cells (DCs) with
a plasma cell-like morphology that exhibits immunomodulating activity. Plasmacytoid
dendritic cells (pDCs) express a characteristic set of surface markers, such as CD123
(interleukin-3 receptor alpha chain), BDCA-2 (blood dendritic cell antigen 2; CD303)
and BDCA-4 (CD304), as well as intracellular toll-like receptors 7 and 9. Upon stimulation,
the activated pDCs produce substantial amounts of interferon (IFN) alpha, and to a
lesser degree IFN-beta, as well as other cytokines and chemokines, such as tumor necrosis
factor alpha and interleukins 1, 6 and 8. In addition, these pDCs, directly or indirectly
stimulate T-cells, B-cells and natural killer cells. This may potentially lead to
increased immunity against tumor cells.;
NCI Metathesaurus CUI : CL437432;
Origin ID : C103192;
UMLS CUI : C3641120;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
