Preferred Label : Modified Citrus Pectin Supplement;
NCIt definition : A dietary supplement containing the modified citrus pectin (MCP) derived from the
soluble fiber of citrus fruit peels and a galectin-3 inhibitor with potential antioxidant,
hypocholesterolemic, immunostimulatory, metal chelating, and anti-metastatic activities.
MCP is a low molecular weight version of pectin composed of short, slightly-branched
carbohydrate chains and is modified for enhanced absorbability. The bioactive fragments,
most likely the galactan-containing portion, of pectin binds to galectin-3, a carbohydrate-binding
protein involved in imflammation, heart disease and is upregulated on the surface
of certain types of tumor cells. Binding of MCP may result in the suppression of cancer
cell aggregation, adhesion, proliferation and metastasis. In addition, MCP decreases
prostate specific antigen (PSA) levels and may remove heavy metals. Also, unsaturated
oligogalacturonic acids in MCP may stimulate the immune system through the activation
of natural killer cells, cytotoxic T-cells, and B-cells.;
Drug name : PectaSol-C;
NCI Metathesaurus CUI : CL437425;
Origin ID : C103178;
UMLS CUI : C3641110;
Semantic type(s)
- concept_is_in_subset
