3-Chlorotyrosine

Preferred Label : 3-Chlorotyrosine;

NCIt synonyms : Monochlorotyrosine; L-(8CI)-3-Chloro-Tyrosine; Chlorotyrosine; 3-Chloro-L-Tyrosine; Cl-Tyr;

NCIt definition : A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is produced in proteins with tyrosine residues by the strong oxidant HClO. HClO which is formed at sites of inflammation is also the anti-bacterial molecule produced by neutrophils through MPO-catalyzed oxidation. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme that produces HClO. Therefore, 3-chlorotyrosine can potentially be used to help determine the extent of neutrophilic inflammation.;

UNII : SY44C9MINA;

CAS number : 7423-93-0;

Details

Origin ID

C103150;

UMLS CUI

C0254781;

Automatic exact mappings (from CISMeF team)
- 3-chlorotyrosine [MeSH concept]
CISMeF manual mappings
- 3-chlorotyrosine [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3-chlorotyrosine [MeSH Supplementary Concept]
- 3-chlorotyrosine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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