Preferred Label : Piritrexim;
NCIt synonyms : 6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine; 6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine; 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine;
NCIt related terms : BW 301U;
NCIt definition : A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties.
Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting
folate metabolism and DNA synthesis and cell division. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called folate antagonists.;
UNII : MK2A783ZUT;
InChIKey : VJXSSYDSOJBUAV-UHFFFAOYSA-N;
CAS number : 72732-56-0;
Molecule name : BW-301U;
Chemical formula : C17H19N5O2;
Codes from synonyms : 50547; CDR0000045276; NSC0351521;
Origin ID : C1031;
UMLS CUI : C0054332;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
