Preferred Label : PBN Derivative OKN-007;
Obsolete resource : true;
NCIt synonyms : 2,4-Disulfonyl PBN; 2,4-Disulfophenyl-tert-butylnitrone;
NCIt definition : A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma
activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown,
this agent appears to inhibit cancer cell proliferation and migration. This agent
appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase
that is overexpressed in the extracellular matrix of cancer cells and catalyzes the
removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may
induce changes in tumor metabolism and scavenge free radicals.;
NCIt note : See 'Disufenton Sodium(C77600)';
Concept status : Retired_Concept;
CAS number : 168021-79-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 168021-79-2
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G-SRS /a ;
Molecule name : OKN-007; NXY-059;
Origin ID : C102983;
UMLS CUI : C2974636;
Semantic type(s)
- UMLS correspondences (same concept)
- OKN 007 [MeSH Supplementary Concept]
