Preferred Label : Everolimus Tablets for Oral Suspension;
NCIt definition : Tablets for oral suspension containing everolimus, a derivative of the natural macrocyclic
lactone sirolimus, with immunosuppressive and antineoplastic activities. After suspension
of the everolimus tablets in water and oral administration, this agent inhibits the
activation of the serine/threonine kinase mammalian target of rapamycin (mTOR) by
binding to mTOR's cytosolic receptor immunophilin FK Binding Protein-12 (FKBP-12).
Inhibition of the mTOR complex may result in the inhibition of the phosphatidylinositol
3 kinase/Akt/mTOR pathway and an inhibition in the expression of vascular endothelial
cell growth factor (VEGF) and hypoxia-inducible factor. Ultimately, this may result
in decreased tumor cell proliferation and tumor angiogenesis. This pediatric formulation
can dissolve easily in a small volume of water making it easier to swallow and is
available in smaller dose increments thereby allowing for greater dosing flexibility.;
Drug name : Afinitor Disperz;
NCI Metathesaurus CUI : CL437183;
Origin ID : C102880;
UMLS CUI : C3640992;
Semantic type(s)
- concept_is_in_subset
