Nanoparticle-encapsulated Doxorubicin Hydrochloride

Preferred Label : Nanoparticle-encapsulated Doxorubicin Hydrochloride;

NCIt definition : A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration, doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells.;

Drug name : Doxorubicin Transdrug; Livatag;

Molecule name : BA-003;

NCI Metathesaurus CUI : CL437178;

Details

Origin ID

C102875;

UMLS CUI

C3640985;

Automatic exact mappings (from CISMeF team)
- DOXOrubicin [LOINC component]
- Doxorubicin (substance) [SNOMED CT concept]
- doxorubicin [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Doxorubicin [SMS substance]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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