Preferred Label : Nanoparticle-encapsulated Doxorubicin Hydrochloride;
NCIt definition : A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline
antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration,
doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and
causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition
and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation.
Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors
and may circumvent the tumor cells multidrug resistance mechanisms and may therefore
be effective in chemoresistant tumor cells.;
Drug name : Doxorubicin Transdrug; Livatag;
Molecule name : BA-003;
NCI Metathesaurus CUI : CL437178;
Origin ID : C102875;
UMLS CUI : C3640985;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
