Preferred Label : Ulinastatin;
NCIt synonyms : Urinary Trypsin Inhibitor; UTI; Bikunin; Trypsin Inhibitor, Bikunin;
NCIt definition : A multivalent Kunitz-type serine protease inhibitor derived from human urine, with
potential protective, anti-fibrinolytic and anticoagulant activities. Upon administration,
ulinastatin (or urinary trypsinogen inhibitor) inhibits the activities of a variety
of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase,
cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear
leukocyte elastase. In addition, ulinastatin inhibits the excessive release of proinflammatory
mediators, such as tumor necrosis factor-alpha, interleukin-6 and -8, and chemokines.
Altogether, this agent may improve the microcirculation, perfusion and function of
tissues and may protect organ injury.;
UNII : OR3S9IF86U;
CAS number : 80449-32-7;
Origin ID : C102851;
UMLS CUI : C0077906;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
