Preferred Label : Naphthalimide Analogue UNBS5162;
NCIt synonyms : 1-(2-(2-(Dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea;
NCIt related terms : UNBS-5162;
NCIt definition : An amonafide (naphthalimide) derivative and pan-antagonist of chemokine ligand (CXCL)
expression, with potential anti-angiogenic activity. Although UNBS5162 is a derivative
of amonafide, this agent appears to have a different profile to that of amonafide
and its exact mechanism of action remains to be fully elucidated. This agent seems
to decrease the expression of various proangiogenic CXCL chemokines in vitro and may
have synergistic effects with radiotherapy or chemotherapy. CXCLs are small cytokines
in the CXC chemokine family that are overexpressed in certain cancers; CXCL-mediated
signaling plays a key role in angiogenesis and tumor progression.;
UNII : JY9JF7D78N;
CAS number : 956590-23-1;
Molecule name : UNBS5162;
Origin ID : C102850;
UMLS CUI : C2603824;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
