Preferred Label : CK2-targeting Synthetic Peptide CIGB-300;
NCIt related terms : CIBG-300;
NCIt definition : A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential
antineoplastic activity. Upon administration and nucleolar localization, CK2-targeting
synthetic peptide CIGB-300 binds to phosphoacceptor sites on the CK2 substrates, in
particular the oncoprotein nucleophosmin (B23 or NPM1). This blocks the activation
of B23 and induces apoptosis, thereby inhibiting tumor cell growth in susceptible
tumor cells. CK2, a protein kinase often overexpressed in a variety of cancer cell
types, appears to be correlated with malignant transformation, tumor growth and survival.
Overexpression of B23 has been correlated with increased cellular growth and proliferation
as well as inhibition of differentiation and apoptosis.;
UNII : X6HMT2EDH9;
CAS number : 1072877-99-6;
Molecule name : CIGB-300; P15-tat; CIGB-325;
Origin ID : C102849;
UMLS CUI : C2605865;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
