Preferred Label : Carmustine Sustained-Release Implant Wafer;
NCIt definition : A sustained release (SR) implant wafer containing the lipophilic nitrosourea carmustine
(BCNU) with antineoplastic activity. Upon intracranial administration of the implant
wafer and subsequent release of BCNU from the wafer, this agent alkylates and cross-links
DNA during all phases of the cell cycle, resulting in the disruption of DNA function,
cell cycle arrest, and apoptosis. This wafer contains the biodegradable copolymer
PLGA (poly(lactide-co-glycolide) as the major drug delivery vehicle which is slowly
degraded into water and carbon dioxide thereby continously releasing BCNU over approximately
3-4 weeks. Compared to systemic administration of BCNU alone, this local SR formulation
is able to maintain higher drug concentrations locally over a longer period of time
while minimizing exposure to other tissues.;
Drug name : CASANT Wafer;
NCI Metathesaurus CUI : CL437131;
Origin ID : C102847;
UMLS CUI : C3640963;
Semantic type(s)
- concept_is_in_subset
