Preferred Label : Inducible CD4 CD25 Regulatory T Cells;
NCIt synonyms : iTregs;
NCIt definition : Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the
interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating
activity. Inducible CD4 CD25 T regulatory cells (iTregs) are a subset of CD4 T lymphocytes
that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2
and transforming growth factor-beta. These regulatory T cells are essential in maintaining
immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive
T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic
stem cell transplants.;
NCI Metathesaurus CUI : CL437026;
Origin ID : C102789;
UMLS CUI : C3640949;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
