Preferred Label : Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650;
NCIt synonyms : I-124 Anti-PS MoAb PNG650; I-124 PGN650;
NCIt definition : A radioimmunoconjugate composed of the F(ab')2 fragment of human monoclonal antibody
PGN650 against phosphatidylserine (PS) labeled with the radioisotope iodine I 124,
with potential imaging activity upon positron-emission tomography (PET). Upon administration,
the MoAb moiety of PGN650 binds to exposed PS on tumor cells, thereby allowing for
the visualization of tumors upon PET. This may facilitate the assessment of the effectiveness
of antitumor agents. The phospholipid PS is normally located on the inner leaflet
of the plasma membrane of healthy cells but is flipped to the outer leaflet in the
endothelial lining of the tumor vasculature and other tumor cells in response to chemo-
or radio- treatments in addition to oxidative stress.;
NCI Metathesaurus CUI : CL437023;
Origin ID : C102785;
UMLS CUI : C3640946;
Semantic type(s)
- concept_is_in_subset
