Preferred Label : Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9;
NCIt synonyms : iCasp9 Allogeneic T Cells;
NCIt definition : Allodepleted haploidentical T-lymphocytes transduced with the Gal-V pseudotyped retrovirus
vector encoding SFG.iCasp9-2A-deltaCD19, with potential immune reconstitution property.
SFG.iCasp9-2A-deltaCD19 contains the suicide gene inducible caspase 9 (iCasp9) linked
with a 2A-like cleavable peptide to the selectable marker, truncated human CD19 (deltaCD19).
iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V)
linked to human caspase 9 using a short linker (SGGGS). Donor T cell therapy may help
control transplant-related viral infections following allogeneic hematopoietic stem
cell transplantation. However, even the addition of allodepleted donor T cells can
lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop,
the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V
domain activating caspase 9. This results in the death of T cells causing GVHD while
sparing the virus reactive T-cells.;
NCI Metathesaurus CUI : CL437012;
Origin ID : C102757;
UMLS CUI : C3640938;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
