Preferred Label : Zirconium Zr 89-labeled Anti-PlGF Monoclonal Antibody RO5323441;
NCIt synonyms : 89Zr-RO5323441;
NCIt definition : A radioimmunoconjugate comprised of the humanized IgG1 monoclonal antibody directed
against placental growth factor (PlGF) and labeled with zirconium Zr 89 (Zr 89), with
potential radiotracer activity upon positron emission tomography (PET) imaging. The
monoclonal antibody moiety of RO5323441 binds to both PlGF-1 and -2, thereby preventing
the binding of PlGF-1 and -2 to the vascular endothelial growth factor receptor-1
(VEGFR-1) and the subsequent activation of VEGFR-1. The radioisotope moiety of RO5323441
may be detected using PET, thereby allowing for visualization of the antibody's distribution
and PlGF expression. PlGF, a member of the VEGF sub-family and a key molecule in angiogenesis
and vasculogenesis, is upregulated in many cancers.;
Origin ID : C102750;
UMLS CUI : C3640931;
Semantic type(s)
- concept_is_in_subset
