Preferred Label : Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules;
NCIt synonyms : V. myrtillus/M. cordata/E. angustfolia Extract Granules;
NCIt definition : A proprietary suspension formulation prepared from granules of standardized extracts
from the fruits of Vaccinium myrtillus, the aerial parts of Macleaya cordata and the
roots of Echinacea angustifolia, with potential anti-mucositis, anti-inflammatory,
and analgesic activities. The main active ingredients of this formulation include
anthocyanosides and procyanidins, benzophenanthridinic alkaloids, and alkylamides
from V. myrtillus, M. cordata and E. angustifolia extracts, respectively. Upon administration
in the mucosal cavity, the anthocyanosides scavenge free radicals, form a protective
barrier on the mucosa, and protect the integrity of the capillary vessels; the benzophenanthridine
alkaloids prevent the production of pro-inflammatory cytokines by inhibiting NF-kB
and may halt the growth of microorganisms; the alkylamides inhibit cyclooxygenase
and 5-lipoxygenase thereby blocking productions of prostaglandin and leukotriene.
Furthermore, alkylamides modulate the expression of tumor necrosis factor alpha and
other cytokines involved in inflammation processes through cannabinoid type 2 receptors
and as cannabinomimetics they may also exert analgesic activity.;
Drug name : Samital Granules;
NCI Metathesaurus CUI : CL437005;
Origin ID : C102748;
UMLS CUI : C3640928;
Semantic type(s)
- concept_is_in_subset
