Preferred Label : PLED-based MnSOD Mimetic;
NCIt related terms : CALMANGAFODIPIR;
NCIt definition : A derivative of pyridoxyl ethyldiamine (PLED) and mimetic of the human mitochondrial
manganese superoxide dismutase (MnSOD), with antioxidant, metal chelating and potential
chemoprotective activities. Upon administration, PLED-based MnSOD mimetic mimics MnSOD
and scavenges oxygen free radicals such as superoxide anion, hydrogen peroxide, and
hydroxyl radical, thereby preventing oxygen free radical damage to macromolecules
such as DNA and minimizing oxygen free radical-related chemotoxicity in normal tissues.
In addition, this agent is able to strongly bind to iron.;
UNII : N0JZU0WGU5;
CAS number : 1401243-67-1;
Drug name : PLEDOx;
Molecule name : PP-095;
NCI Metathesaurus CUI : CL437004;
Origin ID : C102747;
UMLS CUI : C3640925;
Semantic type(s)
- concept_is_in_subset
