Preferred Label : Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation;
NCIt synonyms : ER Bupivacaine HCl; SABER-Bupivacaine Hydrochloride; Sustained Release Bupivacaine Hydrochloride;
NCIt definition : An extended release (ER) injectable formulation composed of the hydrochloride salt
form of bupivacaine, an amide-type, long-acting local anesthetic, in a resorbable
sucrose acetate isobutyrate-based matrix, with analgesic activity. Following administration
in or around a specific site, ER bupivacaine is released from the matrix over an extended
period of time. Upon release, bupivacaine reversibly binds to specific voltage-gated
sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent
membrane permeability to sodium ions, membrane destabilization, and depolarization
inhibition thus disrupting nerve impulse conduction. This eventually leads to a reversible
loss of sensation. This formulation may provide pain relief up to 72 hours.;
NCI Metathesaurus CUI : CL437002;
Origin ID : C102745;
UMLS CUI : C3640923;
Semantic type(s)
- concept_is_in_subset
