Docetaxel Lipid Microspheres

Preferred Label : Docetaxel Lipid Microspheres;

NCIt synonyms : Docetaxel Lipid Emulsion; DT-LM; DLE;

NCIt definition : A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile.;

NCI Metathesaurus CUI : CL436875;

Details

Origin ID

C102568;

UMLS CUI

C3542918;

Automatic exact mappings (from CISMeF team)
- DLE [WHO-ART Included Term]
- Discoid lupus erythematosus [ICD-11 Subcategory]
- Flotation [LOINC method]
- Flow [LOINC component]
- education, distance [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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