Preferred Label : Ipafricept;
NCIt synonyms : Fusion Protein For Immune Applications (fpia) Comprising Homo Sapiens FZD8 (Frizzled
Family Receptor 8, Frizzled-8) Extracellular Domain, Fused With Homo Sapiens Immunoglobulin
G1 Fc Fragment;
NCIt definition : A proprietary fusion protein comprised of the cysteine-rich domain of frizzled family
receptor 8 (Fzd8) fused to the human immunoglobulin Fc domain with potential antineoplastic
activity. Upon intravenous administration, ipafricept competes with the membrane-bound
Fzd8 receptor for its ligand, Wnt proteins, thereby antagonizing Wnt signaling. This
may result in the inhibition of Wnt-driven tumor growth. Fzd8, a member of the Frizzled
family of G protein-coupled receptors, is one of the components in the Wnt/beta-catenin
signaling pathway that plays key roles in embryogenesis and cancer growth.;
UNII : 2N71QUE3NL;
CAS number : 1391727-24-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1391727-24-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : Fzd8-Fc; OMP-54F28; OMP 54F28;
PubMed : 17545618;
Origin ID : C102565;
UMLS CUI : C3640817;
Semantic type(s)
- concept_is_in_subset
