Preferred Label : Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta;
NCIt synonyms : Recombinant VSV-IFN-beta; VSV-hIFN-b;
NCIt definition : A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the
human interferon-beta (IFN-b) gene, with potential immunomodulating and antineoplastic
activities. Upon intratumoral administration, recombinant VSV expressing IFN-b replicates
in the tumor environment specifically, partially due to defective innate antiviral
host defense mechanisms in tumor cells, involving type I IFNs, and exerts its cytolytic
activity towards the tumor cells. By expressing human IFN-b, an INF-b-mediated antiviral
immune response in surrounding normal cells is activated which protects normal cells
against virus replication and VSV-mediated cell lysis. However, tumor cells have a
defective IFN-b-mediated innate antiviral immune response allowing for VSV to replicate
in these cells without interference. In addition, the IFN-b produced by VSV may activate
an immune response in surrounding normal cells and may activate T-lymphocytes, dendritic
cells and natural killer cells; thus, inducing an anti-tumor immune response against
the tumor cells. VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus
of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans.;
NCI Metathesaurus CUI : CL436814;
Origin ID : C102545;
UMLS CUI : C3640805;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
