PREX2 wt Allele

Preferred Label : PREX2 wt Allele;

NCIt synonyms : 6230420N16Rik; DEP.2; DEPDC2; P-REX2; Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2 wt Allele; FLJ12987;

NCIt definition : Human PREX2 wild-type allele is located in the vicinity of 8q13.2 and is approximately 285 kb in length. This allele, which encodes phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, plays a role in the regulation of small GTPase-dependent signaling.;

NCIt note : Mutation of the PREX2 gene is associated with melanoma. (Nature. 2012; doi:10.1038/nature11071.);

GenBank Accession Number : AK024079;

Details

Origin ID

C102518;

UMLS CUI

C3537461;

OMIM relation
- Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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