NCIt definition : A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase
enzyme inhibitor clavulanate potassium. Clavulanate potassium increases the serum
half-life of amoxicillin by inhibiting beta-lactamase-mediated metabolism of amoxicillin.
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin binding
proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial
cell walls.;
Alternative definition : NCI-GLOSS: A drug used to treat bacterial infections. Adding the chemical clavulanate
potassium to the antibiotic amoxicillin increases the amount of time the antibiotic
stays active in the body. Amoxicillin-clavulanate potassium is a type of combination
antibiotic.;
Drug name : Augmentin;
Codes from synonyms : CDR0000572144; CDR0000538642;