Preferred Label : Emitefur;
NCIt synonyms : 3-[3-(6-Benzoyloxy-3-cyrano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil; [[Ethoxymethyl-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid,
6-(Benzoyloxy)-3-cyano-2-pyridinyl Ester; 3-((3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl)carbonyl)benzoic
acid, 6-(benzoyloxy)-3-cyano-2-pyridinyl ester; (2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic
Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester);
NCIt definition : An orally available antimetabolite composed of the 1-ethoxymethyl derivative of 5-fluorouracil
(5-FU) and the dihydropyrimidine dehydrogenase (DPYD) inhibitor 3-cyano-2,6-dihydroxypyridine
(CNDP) in a 1:1 molar ratio, with antineoplastic activity. Upon administration, the
prodrug emitefur is converted into 5-FU, while CNDP prevents the degradation of 5-FU
by inhibiting DPYD and thereby prolonging the half-life of 5-FU. This increases 5-FU's
concentration and thus its antitumor activity through inhibition of DNA and RNA synthesis,
as well as inhibition of thymidylate synthase activity. In addition, by inhibiting
the formation of 5-FU metabolites, some toxic effects associated with these metabolites
may be reduced. DPYD is the rate-limiting enzyme in the catabolism of 5-FU.;
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;
UNII : 9I50NF4AQ2;
InChIKey : WTSKMKRYHATLLL-UHFFFAOYSA-N;
CAS number : 110690-43-2;
Drug name : Last-F;
Molecule name : BOF-A2;
Chemical formula : C28H19FN4O8;
Codes from synonyms : CDR0000045578;
Origin ID : C1022;
UMLS CUI : C0053902;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
