Preferred Label : Poly-alendronate Dextran-Guanidine Conjugate;
NCIt synonyms : Dextran/Alendronate/Guanidine-containing Polybisphosphonate; ODX;
NCIt definition : A polybisphosphonate dextran-guanidine conjugate with potential anti-resorptive and
antineoplastic activities. Alendronic acid and aminoguanidine were conjugated sequentially
to oxidized dextran resulting in an average of 8 alendronate and 50 guanidine groups
coupled to the dextran backbone. Upon administration, the poly-alendronate dextran-guanidine
conjugate inhibits the mevalonate pathway by inhibiting farnesyl diphosphate synthase
(FDPS) which leads to a reduction in protein prenylation and to the loss of downstream
metabolites essential for osteoclast function. This eventually leads to the induction
of apoptosis in osteoclasts. Also, by preventing osteoclast-mediated bone resorption,
this agent decreases bone turnover and stabilizes the bone matrix. The guanidine moiety
increases the nitrogen content and possibly the activity of the bisphosphonate and
its ability to inhibit FDPS. In addition, the guanidine moiety facilitates cell internalization
and may contribute to this agent's cytotoxicity.;
Drug name : Osteodex;
NCI Metathesaurus CUI : CL436277;
Origin ID : C101894;
UMLS CUI : C3640298;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
