Preferred Label : Allogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo;
NCIt synonyms : PANC 10.05 pcDNA-1/GM-Neo;
NCIt definition : An allogeneic cancer vaccine composed of lethally irradiated, whole pancreatic cancer
cells transfected with a plasmid carrying the gene for cytokine granulocyte-macrophage
colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic
activities. Allogeneic GM-CSF-secreting tumor vaccine PANC 10.05 pcDNA-1/GM-Neo secretes
GM-CSF thereby activating dendritic cells, promoting antigen presentation to B- and
T-cells, and promoting a cytotoxic T-lymphocyte (CTL) response. This may eventually
kill tumor cells. The pancreatic tumor cells are derived from the PANC 10.05 tumor
cell line.;
NCI Metathesaurus CUI : CL436275;
Origin ID : C101892;
UMLS CUI : C3640296;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
