Preferred Label : EphA2-targeting DOPC-encapsulated siRNA;
NCIt synonyms : siRNA-EphA2-DOPC;
NCIt definition : A liposomal formulation consisting of short-interfering RNAs (siRNAs) directed against
ephrin type-A receptor 2 (EphA2) and encapsulated into 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine
(DOPC) neutral liposomes, with potential antineoplastic activity. Upon internalization,
EphA2-targeting DOPC-encapsulated siRNA can hybridize to EphA2 DNA and mRNA, thereby
interfering with both the transcription and translation of EphA2, and thus inhibiting
tumor cell growth. The cell-surface receptor EphA2, a member of the ephrin family
of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed
by a variety of different cancer cell types and plays an important role in tumor growth.;
NCI Metathesaurus CUI : CL436272;
Origin ID : C101889;
UMLS CUI : C3640293;
Semantic type(s)
- concept_is_in_subset
- has_target
