Klebsiella pneumoniae Glycoprotein

Preferred Label : Klebsiella pneumoniae Glycoprotein;

NCIt definition : A glycoprotein complex extracted from Klebsiella pneumoniae K2O1 strain with immunostimulating property. This glycoprotein complex consists of 2 repetitive glycoprotein subunits; P1 comes from the bacterial capsule about 95 kD in molecular mass and F1, having an lipopolysaccharide-related structure (350 kDa), is derived from bacterial external membrane. Although the mechanism of action is not fully elucidated, Klebsiella pneumoniae F1 fraction appears to suppress monocyte apoptosis, hence inducing the differentiation of monocytes into macrophages. Furthermore, this agent also enhances humoral and cell-mediated immune responses, and increases natural killer cell cytotoxicity functions. This glycoprotein has been shown to reduce the incidence of infection.;

CAS number : 68583-24-4;

Drug name : Biostim;

Molecule name : RU 41.740; RU- 41740;

PubMed : 2662280;

Details

Origin ID

C1018;

UMLS CUI

C0892377;

Currated CISMeF NLP mapping
- glycoprotein, klebsiella pneumoniae [MeSH concept]
- glycoprotein, klebsiella pneumoniae [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- glycoprotein, klebsiella pneumoniae [MeSH concept]
- glycoprotein, klebsiella pneumoniae [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Biostim/Doxorubicin/Etoposide/Prednisone [NCIt concept]
- Biostim/Melphalan/Prednisone/Vincristine [NCIt concept]

Keyword's position in hierarchy(ies) :

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