Preferred Label : Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes;
NCIt synonyms : Allogeneic Adenovirus-specific CTLs;
NCIt definition : A population of allogeneic cytotoxic T-lymphocytes (CTLs) specifically reactive to
human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities.
Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific
CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing
Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised
hosts. These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation
with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have
been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene.;
NCI Metathesaurus CUI : CL435914;
Origin ID : C101796;
UMLS CUI : C3640224;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
