Preferred Label : TORC1/2 Kinase Inhibitor DS-3078a;
NCIt definition : An orally bioavailable inhibitor of raptor-mTOR protein complex (TORC1) and rictor-mTOR
protein complex (TORC2) with potential antineoplastic activity. TORC1/2 inhibitor
DS-3078a binds to and inhibits both TORC1 and TORC2, which may result in tumor cell
apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated
in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway,
which is frequently dysregulated in human cancers.;
Molecule name : DS-3078a;
NCI Metathesaurus CUI : CL435913;
Origin ID : C101795;
UMLS CUI : C3640223;
Semantic type(s)
- concept_is_in_subset
