NCIt definition : A formulation of the 6-omega fatty acid derivative 2'-linoleyl carbonate (LOC) conjugated
to paclitaxel, a taxane compound extracted from the Pacific yew tree Taxus brevifolia,
with potential antineoplastic activity. Paclitaxel binds to and stabilizes tubulin,
thereby interfering with the dynamics of microtubule assembly/disassembly and resulting
in the inhibition of cell division. LOC enhances the uptake of paclitaxel by tumor
cells, thereby concentrating this agent in tumor cells compared to normal cells, and
may decrease its toxicity profile; fatty acids serve as energy sources and biochemical
precursors for the fast growing tumor cells.;
Semantic type(s)