Preferred Label : Multi-AGC Kinase Inhibitor AT13148;
NCIt related terms : AT-13148;
NCIt definition : An orally available, small molecule inhibitor of AGC group kinases, with potential
antineoplastic activity. AT13148 inhibits, in an ATP-competitive manner, the enzymatic
activity of two AGC kinases, protein kinase B (PKB or AKT) and p70S6K which play key
roles in the PI3K/PKB/mTOR signaling pathway. Blockade of this pathway leads to an
inhibition of cell growth and the induction of apoptosis in susceptible tumor cells.
PI3K/PKB/mTOR pathway is dysregulated in greater than 50% of tumors, and is often
correlated with resistance and increased tumor survival. AGC group kinases are serine/threonine
kinases that are regulated by secondary messengers such as cyclic AMP and lipids.;
UNII : A49037RP1E;
CAS number : 1056901-62-2;
Molecule name : AT13148;
Origin ID : C101786;
UMLS CUI : C3640215;
Semantic type(s)
- UMLS correspondences (same concept)
- AT13148 [MeSH Supplementary Concept]
- concept_is_in_subset
