Preferred Label : Lipegfilgrastim;
NCIt synonyms : Pegylated granulocyte colony stimulating factor (human short isoform) O(sup 3.137)-((3,5-dideoxy-5-((N-((omega-methoxypoly(oxyethylene))carbonyl)glycyl)amino)-D-
glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2- 6)-2-(acetylamino)-2-deoxy-alpha-D-
galactopyranosyl)-des-(37-39)-(1-methionine)human granulocyte colony-stimulating factor
(G-CSF, pluripoietin); Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-methoxy-, 133-ester with granulocyte colony-stimulating
factor (methionyl,133-(O-(2-(acetylamino)-6-O-(N-((N- carboxyglycyl)amino)-alpha-neuraminosyl)-2-deoxy-alpha-D-galactopyranosyl)-L-threonine))
(human);
NCIt definition : A long acting glyco-pegylated recombinant form of human granulocyte colony-stimulating
factor (G-CSF), with hematopoietic activity. Similar to G-CSF, lipegfilgrastim binds
to and activates specific cell surface receptors, and stimulates neutrophil progenitor
proliferation and differentiation. Therefore, this agent may prevent the duration
and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, lipegfilgrastim
has a prolonged plasma half-life.;
UNII : 4AWF0N6QV3;
CAS number : 1117844-87-7;
Drug name : Lonquest; Lonquex;
Molecule name : XM22;
Origin ID : C101778;
UMLS CUI : C3640212;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
