Preferred Label : MEK Inhibitor WX-554;
NCIt definition : An orally available small molecule mitogen-activated protein kinase kinase (MAP2K,
MAPK/ERK kinase, or MEK) inhibitor, with potential antineoplastic activity. MEK inhibitor
WX-554 selectively binds to and inhibits the activity of MEK, thereby preventing the
activation of MEK-dependent effector proteins including some transcription factors,
which may result in the inhibition of growth factor-mediated cell signaling and tumor
cell proliferation. MEK, a dual-specificity threonine/tyrosine kinase that plays a
key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently
upregulated in a variety of tumor cell types.;
Molecule name : WX-554;
NCI Metathesaurus CUI : CL435784;
Origin ID : C101532;
UMLS CUI : C3640133;
Semantic type(s)
- concept_is_in_subset
